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Am J Respir Crit Care Med. 2010 Jan 15;181(2):168-73. doi: 10.1164/rccm.200906-0970OC. Epub 2009 Nov 12.

Prognostic factors for pulmonary embolism: the prep study, a prospective multicenter cohort study.

Author information

1
Service de Pneumologie et Soins Intensifs, Hôpital Européen Georges Pompidou, 20 rue Leblanc 75015 Paris, France. olivier.sanchez@egp.aphp.fr

Abstract

RATIONALE:

The short-term prognosis of pulmonary embolism (PE) depends on hemodynamic status and underlying disease. The prognostic value of right ventricular dysfunction and injury is less well established.

OBJECTIVES:

To evaluate prognostic factors of PE in a multicenter prospective cohort study.

METHODS:

Echocardiography, brain natriuretic peptide (BNP), N-terminal-proBNP and cardiac troponin I measurements were done on admission of 570 consecutive patients with an acute PE. A predictive model was based on independent predictors of 30-day adverse events defined as death, secondary cardiogenic shock, or recurrent venous thromboembolism.

MEASUREMENTS AND MAIN RESULTS:

At 30 days, 42 patients (7.4%; 95% confidence interval [CI], 5.5-9.8%) had adverse events. On multivariate analysis, altered mental state (odds ratio [OR] 6.8; 95% confidence interval [CI], 2.0-23.3), shock on admission (OR 2.8; 95% CI, 1.1-7.5), cancer (OR 2.9; 95% CI, 1.2-6.9), BNP (OR 1.3 for an increase of 250 ng/L; 95% CI, 1.1-1.6) and right to left ventricle diameter ratio (OR 1.2 for an increase of 0.1; 95% CI, 1.1-1.4) were associated with 30-days of adverse events. The predictive performance of the model was good (area under receiver operating characteristics curve 0.84 [95% CI, 0.78-0.90]), making it possible to develop a bedside prognostic score.

CONCLUSIONS:

BNP and echocardiography may be useful determinants of the short-term outcome for patients with PE, together with clinical findings. Patients with PE can be stratified according to the initial risk of adverse outcome, using a simple score based on clinical, echocardiographic, and biochemical variables.

PMID:
19910608
DOI:
10.1164/rccm.200906-0970OC
[Indexed for MEDLINE]

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