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Curr Opin Chem Biol. 2010 Feb;14(1):50-6. doi: 10.1016/j.cbpa.2009.10.014. Epub 2009 Nov 10.

Mitochondrial-targeted fluorescent probes for reactive oxygen species.

Author information

1
Department of Chemistry, University of California, Berkeley, CA 94720, USA.

Abstract

As the primary consumers of oxygen within all aerobic organisms, mitochondria are a major source of cellular reactive oxygen species (ROS) derived from the in vivo chemistry of oxygen metabolism. Mitochondrial ROS have been traditionally implicated in aging and in a variety of pathologies, including cancer, neurodegeneration, and diabetes, but recent studies also link controlled mitochondrial ROS fluxes to cell regulation and signaling events. Progress in the development of mitochondrial-targeted fluorescent small-molecule indicators that detect specific ROS with high selectivity offers a promising approach for interrogating mitochondrial ROS production, trafficking, and downstream biological effects.

PMID:
19910238
PMCID:
PMC2830890
DOI:
10.1016/j.cbpa.2009.10.014
[Indexed for MEDLINE]
Free PMC Article

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