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Bioorg Med Chem Lett. 2010 Jan 1;20(1):248-51. doi: 10.1016/j.bmcl.2009.10.121. Epub 2009 Oct 30.

Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.

Author information

1
Sandwich Laboratories, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. david.blakemore@pfizer.com

Abstract

A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against alpha(2)delta and was profiled in in vivo models of pain and anxiety.

PMID:
19910190
DOI:
10.1016/j.bmcl.2009.10.121
[Indexed for MEDLINE]

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