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J Allergy Clin Immunol. 2009 Dec;124(6):1197-203. doi: 10.1016/j.jaci.2009.08.042.

Dispensing of fluticasone propionate/salmeterol combination in the summer and asthma-related outcomes in the fall.

Author information

1
Jacqueline Neimark Laboratory ofClinical Pharmacology in Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA. spahnj@njc.org

Abstract

BACKGROUND:

Asthma exacerbations occur year-round; however, peak asthma-related events occur in the fall and are frequently associated with viral respiratory infections.

OBJECTIVE:

To compare the rates of asthma-related emergency department (ED) visits and hospitalizations in the fall (September, October, November) between users and nonusers of fluticasone propionate plus salmeterol in a single inhaler (FSC) in the preceding summer.

METHODS:

This was a retrospective, observational study using health care claims from a large managed care database. Patients age 4 to 55 years with both a medical claim for asthma and a pharmacy claim for FSC were categorized into 3 age groups: children (4-11 years), adolescents (12-18 years), and adults (19-55 years).

RESULTS:

There were 201,973 observations of FSC dispensings and 184,143 observations without FSC. Across all age groups, summertime dispensings of FSC were associated with a significantly lower (P < .001) risk of an asthma-related ED visit (4-11 years: adjusted odds ratio [OR], 0.54, 95% CI, 0.49-0.60; 12-18 years: OR, 0.59, 95% CI, 0.54-0.64; 19-55 years: OR, 0.53, 95% CI, 0.51-0.55) or hospitalization (4-11 years: OR, 0.43, 95% CI, 0.35-0.54; 12-18 years: OR, 0.49, 95% CI, 0.40-0.60; 19-55 years: OR, 0.61, 95% CI, 0.57-0.65) in the subsequent fall. This protective effect persisted even for patients with fall dispensings of FSC. The risk of oral corticosteroid dispensing in the fall was also significantly reduced in all age groups.

CONCLUSION:

Summertime dispensings of FSC were associated with a decreased risk of serious asthma-related outcomes in the subsequent fall. Continuous use of FSC before seasonal viral exposure may decrease seasonally related exacerbations.

PMID:
19910037
DOI:
10.1016/j.jaci.2009.08.042
[Indexed for MEDLINE]

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