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Adv Drug Deliv Rev. 2010 Mar 8;62(3):339-45. doi: 10.1016/j.addr.2009.11.006. Epub 2009 Nov 10.

Targeted hyperthermia using metal nanoparticles.

Author information

1
The Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

Abstract

Despite the use of hyperthermia to treat cancer for thousands of years, the challenge of only heating malignant cells remains daunting. In pre-clinical and early clinical trials, metal nanoparticles induce hyperthermic cytotoxicity when exposed to near-infrared radiation or radiofrequency fields. We discuss the emerging roles of nanoparticles, especially gold, in the hyperthermic treatment of cancer. In addition, we discuss the similarities of radiofrequency ablation and nanoparticle mediated cytotoxicity.

PMID:
19909777
PMCID:
PMC2827640
DOI:
10.1016/j.addr.2009.11.006
[Indexed for MEDLINE]
Free PMC Article

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