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J Clin Psychiatry. 2009;70 Suppl 5:7-11. doi: 10.4088/JCP.8157su1c.02.

Omega-3 fatty acids in major depressive disorder.

Author information

1
Center for Women's Mental Health, Massachusetts General Hospital, Simches Research Building, 185 Cambridge St, Boston, MA 02114, USA. mfreeman@partners.org

Abstract

Patients with major depressive disorder have high rates of cardiovascular disease and other medical comorbidity. Omega-3 fatty acids, particularly those found in fish and seafood, have cardiovascular health benefits and may play an adjunctive role in the treatment of mood disorders. However, existing studies on omega-3 fatty acids in depression have limitations such as small sample sizes and a wide variance in study design, and results regarding efficacy are mixed. The preponderance of data from placebo-controlled treatment studies suggests that omega-3 fatty acids are a reasonable augmentation strategy for the treatment of major depressive disorder. More research is necessary before omega-3 supplements can be recommended as monotherapy for the treatment of depression. For many individuals with major depressive disorder, augmentation with omega-3 fatty acids should be considered, as general health benefits are well established and adjunctive use is low risk.

PMID:
19909687
DOI:
10.4088/JCP.8157su1c.02
[Indexed for MEDLINE]
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