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Biochem Soc Trans. 2009 Dec;37(Pt 6):1385-8. doi: 10.1042/BST0371385.

Spare respiratory capacity, oxidative stress and excitotoxicity.

Author information

1
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA. dnicholls@buckinstitute.org

Abstract

Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.

PMID:
19909281
DOI:
10.1042/BST0371385
[Indexed for MEDLINE]

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