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Biochem Soc Trans. 2009 Dec;37(Pt 6):1287-92. doi: 10.1042/BST0371287.

Gene expression networks: competing mRNA decay pathways in mammalian cells.

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1
Department of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. lynne_maquat@urmc.rochester.edu

Abstract

Nonsense-mediated mRNA decay and Staufen1-mediated mRNA decay are mechanistically related pathways that serve distinct purposes. In the present article, we give an overview of each pathway. We describe how a factor that is common to both pathways results in their competition. We also explain how competition between the two pathways contributes to the differentiation of C2C12 myoblasts to multinucleated myotubes.

PMID:
19909264
PMCID:
PMC3711687
DOI:
10.1042/BST0371287
[Indexed for MEDLINE]
Free PMC Article
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