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Nucleic Acids Res. 2010 Jan;38(Database issue):D670-5. doi: 10.1093/nar/gkp957. Epub 2009 Nov 11.

Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes.

Author information

1
Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy.

Abstract

The Network of Cancer Genes (NCG) collects and integrates data on 736 human genes that are mutated in various types of cancer. For each gene, NCG provides information on duplicability, orthology, evolutionary appearance and topological properties of the encoded protein in a comprehensive version of the human protein-protein interaction network. NCG also stores information on all primary interactors of cancer proteins, thus providing a complete overview of 5357 proteins that constitute direct and indirect determinants of human cancer. With the constant delivery of results from the mutational screenings of cancer genomes, NCG represents a versatile resource for retrieving detailed information on particular cancer genes, as well as for identifying common properties of precompiled lists of cancer genes. NCG is freely available at: http://bio.ifom-ieo-campus.it/ncg.

PMID:
19906700
PMCID:
PMC2808873
DOI:
10.1093/nar/gkp957
[Indexed for MEDLINE]
Free PMC Article

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