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Curr Biol. 2009 Sep 15;19(17):R772-80. doi: 10.1016/j.cub.2009.07.063.

Domain-driven morphogenesis of cellular membranes.

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1
Laboratory of Cellular and Molecular Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1855, USA.

Abstract

Cellular membrane systems delimit and organize the intracellular space. Most of the morphological rearrangements in cells involve the coordinated remodeling of the lipid bilayer, the core of the membranes. This process is generally thought to be initiated and coordinated by specialized protein machineries. Nevertheless, it has become increasingly evident that the most essential part of the geometric information and energy required for membrane remodeling is supplied via the cooperative and synergistic action of proteins and lipids, as cellular shapes are constructed using the intrinsic dynamics, plasticity and self-organizing capabilities provided by the lipid bilayer. Here, we analyze the essential role of proteo-lipid membrane domains in conducting and coordinating morphological remodeling in cells.

PMID:
19906579
PMCID:
PMC3541010
DOI:
10.1016/j.cub.2009.07.063
[Indexed for MEDLINE]
Free PMC Article
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