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Patient Educ Couns. 2010 Jul;80(1):29-41. doi: 10.1016/j.pec.2009.09.033. Epub 2009 Nov 10.

Mediating the effect of self-care management intervention in type 2 diabetes: a meta-analysis of 47 randomised controlled trials.

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Institute of Clinical Research, Faculty of Health Sciences, Denmark.



To perform a meta-analysis assessing the effects of self-care management interventions in improving glycaemic control in type 2 diabetes by analysing the impact of different study characteristics on the effect size.


A literature search in eight scientific databases up to November 2007 included original studies of randomised controlled trials involving adult patients diagnosed with type 2 diabetes and evaluating a self-care management intervention.


The 47 included studies yielded 7677 participants. The analysis showed a 0.36% (95% CI 0.21-0.51) improvement in glycaemic control in people who received self-care management treatment. In the univariate meta-regression sample size (effect size 0.42%, p=0.007) and follow-up period (effect size 0.49%, p=0.017) were identified to have significant effect on the effect size in favour of small studies and short follow-up. For type of intervention and duration of intervention there was a non-significant effect on effect size in favour of educational techniques and short interventions.


In type 2 diabetes, there are improvements in glycaemic control in people who receive self-care management treatment with a small advantage to intervention with an educational approach.


Further research on frequency and duration of intervention may provide useful information to identify the most effective regime.

[Indexed for MEDLINE]

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