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Chem Commun (Camb). 2009 Dec 7;(45):7033-5. doi: 10.1039/b909666c. Epub 2009 Oct 13.

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous.

Author information

1
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.

Abstract

C1-alkyl AI-2 analogues do not induce bioluminescence in V. harveyi on their own but enhance the bioluminescence induced by AI-2 in a synergistic fashion. A new facile synthesis of AI-2 facilitates the synthesis of a diverse set of AI-2 analogues and biological screening suggests that receptors that are involved in the synergistic bioluminescence production in V. harveyi are promiscuous.

PMID:
19904385
DOI:
10.1039/b909666c
[Indexed for MEDLINE]

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