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Nat Rev Neurosci. 2009 Dec;10(12):885-92. doi: 10.1038/nrn2753. Epub 2009 Nov 11.

A new perspective on the role of the orbitofrontal cortex in adaptive behaviour.

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1
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. schoenbg@schoenbaumlab.org

Abstract

The orbitofrontal cortex (OFC) is crucial for changing established behaviour in the face of unexpected outcomes. This function has been attributed to the role of the OFC in response inhibition or to the idea that the OFC is a rapidly flexible associative-learning area. However, recent data contradict these accounts, and instead suggest that the OFC is crucial for signalling outcome expectancies. We suggest that this function--signalling of expected outcomes--can also explain the crucial role of the OFC in changing behaviour in the face of unexpected outcomes.

PMID:
19904278
PMCID:
PMC2835299
DOI:
10.1038/nrn2753
[Indexed for MEDLINE]
Free PMC Article
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