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Future Oncol. 2009 Nov;5(9):1449-75. doi: 10.2217/fon.09.97.

Molecular and cellular biology of rhabdomyosarcoma.

Author information

1
Department of Experimental Pathology, Cancer Research Section, University of Bologna, Bologna, Italy.

Abstract

Rhabdomyosarcoma is a group of soft-tissue sarcomas that share features of skeletal myogenesis, but show extensive heterogeneity in histology, age and site of onset, and prognosis. This review matches recent molecular data with biological features of rhabdomyosarcoma. Alterations in molecular pathways, animal models, cell of origin and potential new therapeutic targets are discussed.

PMID:
19903072
DOI:
10.2217/fon.09.97
[Indexed for MEDLINE]

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