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Org Lett. 2009 Dec 3;11(23):5370-3. doi: 10.1021/ol901999f.

Synthesis of biphenyl proteomimetics as estrogen receptor-alpha coactivator binding inhibitors.

Author information

1
Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, USA.

Abstract

A novel series of biphenyl proteomimetic compounds were designed as estrogen receptor-alpha (ER(alpha)) coactivator binding inhibitors. Synthesis was accomplished through a convergent approach, employing Suzuki coupling chemistry to ligate the individual modular units. Initial biological results support the ability of these compounds to compete for the ER(alpha) coactivator binding groove.

PMID:
19902964
PMCID:
PMC3263526
DOI:
10.1021/ol901999f
[Indexed for MEDLINE]
Free PMC Article

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