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Bull Exp Biol Med. 2009 Jul;148(1):23-5.

Effect of afobazole on mitochondrial monoamine oxidase A activity in vitro.

Author information

1
Laboratory for Pharmacogenetics, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. niipharm@mail.ru

Abstract

Selective anxiolytic afobazole (1 mM) inhibits monoamine oxidase A activity in mitochondria from rat brain and liver (IC(50) 0.36 and 0.43, respectively). Effect of the compound does not depend on the time of preincubation with mitochondria. Triple washout of mitochondria is followed by complete recovery of initial enzyme activity.

PMID:
19902087
[Indexed for MEDLINE]

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