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Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):441-8. doi: 10.1016/j.cytogfr.2009.10.020. Epub 2009 Nov 8.

BMP-6 and mesenchymal stem cell differentiation.

Author information

1
Laboratory of Mineralized Tissues, Center for Translational Research, School of Medicine, University of Zagreb, Salata 5, 10000 Zagreb, Croatia. vukicev@mef.hr

Abstract

Bone morphogenetic protein-6 (BMP-6) is produced by bone marrow-mesenchymal (BMSC) and hematopoietic stem cells, which can differentiate into bone, cartilage, adipose, muscle, hematopoietic, synovial and other tissues. Bmp6-/- null mice have low hepcidin serum levels and an iron overload, resembling hereditary hemochromatosis, which may cause a reduced number of pancreatic beta-cells, increased serum glucose and diabetes. BMP-6 circulates in the normal human plasma and is produced by BMSC prior to differentiation into osteoblasts. Moreover, it is also released by osteoclasts as a key bone coupling factor recruiting osteoblasts to the resorption site. Due to unique structural, receptor binding and signaling characteristics much smaller amounts of BMP-6 than BMP-7 are needed in vivo to induce regeneration of bone defects in animals.

PMID:
19900832
DOI:
10.1016/j.cytogfr.2009.10.020
[Indexed for MEDLINE]

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