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Cancer Lett. 2010 May 1;291(1):120-9. doi: 10.1016/j.canlet.2009.10.004. Epub 2009 Nov 8.

Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma.

Author information

1
Department of Biology, The University of North Carolina at Charlotte, 28223, USA.

Abstract

Chronic ethanol consumption is a known risk factor for developing hepatocellular carcinoma (HCC). The use of plant-derived antioxidants is gaining increasing clinical prominence as a potential therapy to ameliorate the effects of ethanol on hepatic disease development and progression. This study demonstrates silibinin, a biologically active flavanoid derived from milk thistle, inhibits cytochrome p4502E1 induction, ethanol metabolism and reactive oxygen species generation in HCC cells in vitro. These silibinin-mediated effects also inhibit ethanol-dependent increases in HCC cell proliferation in culture.

PMID:
19900758
PMCID:
PMC3099213
DOI:
10.1016/j.canlet.2009.10.004
[Indexed for MEDLINE]
Free PMC Article

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