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Cancer Lett. 2010 May 1;291(1):99-107. doi: 10.1016/j.canlet.2009.10.005. Epub 2009 Nov 8.

Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma.

Author information

1
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taiwan.

Abstract

We compared microRNA profiles between choriocarcinoma and non-cancerous trophoblasts, and revealed that miR-199b was underexpressed in choriocarcinoma. By computational prediction and microarray studies, SET (protein phosphatase 2A inhibitor) was shown to be one of the target genes regulated by miR-199b. Ectopic expression of miR-199b inhibited endogenous SET protein levels and the activity of the luciferase reporter containing the 3'-UTR of SET. Further comparisons of formalin-fixed paraffin-embedded human choriocarcinoma, mole, and non-cancer trophoblast tissues confirmed the initial findings of low miR-199b expression and SET upregulation in choriocarcinomas, suggesting that microRNA-dysregulated SET protein may account for the rapid growth seen with choriocarcinomas.

PMID:
19900756
DOI:
10.1016/j.canlet.2009.10.005
[Indexed for MEDLINE]

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