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J Am Acad Dermatol. 2010 Jun;62(6):1013-30. doi: 10.1016/j.jaad.2009.06.048. Epub 2009 Nov 8.

Efficacy and safety of treatments for childhood psoriasis: a systematic literature review.

Author information

1
Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. M.deJager@derma.umcn.nl

Abstract

BACKGROUND:

Evidence-based recommendations for therapeutic decision making in childhood psoriasis are lacking.

OBJECTIVES:

We sought to systematically review all available literature concerning treatment efficacy and safety in childhood psoriasis and to propose a recommendation for topical and systemic treatment of childhood psoriasis.

METHODS:

Databases searched were PubMed, EMBASE, and the Cochrane Controlled Clinical Trial Register. All studies reporting on efficacy and safety of all treatment options in childhood psoriasis were obtained and a level of evidence was determined.

RESULTS:

Literature search revealed 2649 studies, of which 64 studies met the inclusion criteria. The majority of topical and systemic therapies given in childhood psoriasis are efficacious. Short-term side effects were usually mild; long-term side effects were not described.

LIMITATIONS:

Most conclusions formulated are not based on randomized controlled trials.

CONCLUSIONS:

A rough summary of the proposed algorithm is as follows: first, calcipotriene with/without topical corticosteroids, followed by dithranol. Methotrexate is considered to be the systemic treatment of choice.

PMID:
19900732
DOI:
10.1016/j.jaad.2009.06.048
[Indexed for MEDLINE]

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