Format

Send to

Choose Destination
Neurobiol Dis. 2010 Feb;37(2):461-7. doi: 10.1016/j.nbd.2009.11.001. Epub 2009 Nov 10.

Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta.

Author information

1
Department of Pediatrics, Neurology Division, D. Geffen School of Medicine at UCLA, 22-474 MDCC, Los Angeles, CA 90095-1752, USA. mazarati@ucla.edu

Abstract

Depression is a frequent comorbidity of temporal lobe epilepsy (TLE); however, its mechanisms remain poorly understood and effective therapies are lacking. Augmentation of hippocampal interleukin-1beta (IL-1beta) signaling may be a mechanistic factor of both TLE and clinical depression. We examined whether pharmacological blockade of hippocampal interleukin-1 receptor exerts antidepressant effects in an animal model of comorbidity between TLE and depression, which developed in Wistar rats following pilocarpine status epilepticus (SE). In post-SE animals, depression-like state was characterized by behavioral equivalents of anhedonia and despair; dysregulation of the hypothalamo-pituitary-adrenocortical axis; compromised raphe-hippocampal serotonergic transmission. Two-week long bilateral intrahippocampal infusion of human recombinant Interleukin-1 receptor antagonist (IL-1ra) improved all of the examined depressive impairments, without modifying spontaneous seizure frequency and without affecting normal parameters in naïve rats. These findings implicate hippocampal IL-1beta in epilepsy-associated depression and provide a rationale for the introduction of IL-1beta blockers in the treatment of depression in TLE.

PMID:
19900553
PMCID:
PMC2818460
DOI:
10.1016/j.nbd.2009.11.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center