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Acta Paediatr. 2010 Mar;99(3):389-93. doi: 10.1111/j.1651-2227.2009.01594.x. Epub 2009 Nov 7.

Vitamin D status and acute lower respiratory infection in early childhood in Sylhet, Bangladesh.

Author information

1
Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Abstract

AIM:

Acute lower respiratory tract infection (ALRI) is the most important global cause of childhood death. Micronutrient deficiencies may increase the risk of ALRI. A case-control study was conducted to assess the association between vitamin D status and ALRI in rural Bangladesh.

METHODS:

Children aged 1-18 months hospitalized with ALRI (cases) were individually matched to controls on age, sex, and village (N = 25 pairs). The mean serum 25-hydroxyvitamin D concentration [25(OH)D] in cases and controls was compared using paired t-test. The unadjusted and adjusted odds of ALRI were assessed by multivariate conditional logistic regression.

RESULTS:

Mean [25(OH)D] was significantly lower among ALRI cases than controls (29.1 nmol/L vs. 39.1 nmol/L; p = 0.015). The unadjusted odds of ALRI was halved for each 10 nmol/L increase in [25(OH)D] (OR 0.53, 95% CI 0.30-0.96). Adjustment for confounders increased the magnitude of the association.

CONCLUSION:

Vitamin D status was associated with early childhood ALRI in a matched case-control study in rural Bangladesh. Randomized trials may establish whether interventions to improve vitamin D status can reduce the burden of ALRI in early childhood.

[Indexed for MEDLINE]

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