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Nat Neurosci. 2009 Dec;12(12):1485-7. doi: 10.1038/nn.2428. Epub 2009 Nov 8.

Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons.

Author information

1
Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA. makaraj@janelia.hhmi.org

Abstract

The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by localized downregulation of A-type K(+) channel function. Thus, dendritic plasticity might be used to store recent experience in individual branches of the dendritic arbor.

PMID:
19898470
DOI:
10.1038/nn.2428
[Indexed for MEDLINE]

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