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Curr Opin Chem Biol. 2010 Feb;14(1):10-4. doi: 10.1016/j.cbpa.2009.10.013. Epub 2009 Nov 10.

Super-resolution optical microscopy: multiple choices.

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Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.


The recent invention of super-resolution optical microscopy enables the visualization of fine features in biological samples with unprecedented clarity. It creates numerous opportunities in biology because vast amount of previously obscured subcellular processes now can be directly observed. Rapid development in this field in the past two years offers many imaging modalities that address different needs but they also complicates the choice of the 'perfect' method for answering a specific question. Here I will briefly describe the principles of super-resolution optical microscopy techniques and then focus on comparing their characteristics in various aspects of practical applications.

[Indexed for MEDLINE]

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