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Bioorg Med Chem Lett. 2009 Dec 15;19(24):6926-30. doi: 10.1016/j.bmcl.2009.10.070. Epub 2009 Oct 21.

New small molecule inhibitors of hepatitis C virus.

Author information

1
Department of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.

Abstract

New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed which allowed identification of dimerization inhibitors of core, the capsid protein of the virus. These compounds were subsequently shown to block production of infectious virus in hepatoma cells.

PMID:
19896376
PMCID:
PMC2783740
DOI:
10.1016/j.bmcl.2009.10.070
[Indexed for MEDLINE]
Free PMC Article

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