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Psychiatry Res. 2009 Dec 30;170(2-3):273-5. doi: 10.1016/j.psychres.2009.01.011. Epub 2009 Nov 6.

Electroconvulsive therapy increases glial cell-line derived neurotrophic factor (GDNF) serum levels in patients with drug-resistant depression.

Author information

1
Department of Neurology, ZhongDa Hospital of Southeast University, Nanjing, 210009, People's Republic of China. zhangxiaobim@163.com

Abstract

Electroconvulsive therapy (ECT) can be effective in patients with depression resistant to pharmacologic medication. We report that serum levels of glial cell-line derived neurotrophic factor (GDNF) were increased following ECT of patients with drug-resistant depression. When patients were sub-classified into ECT responders and non-responders, serum GDNF levels were significantly increased (58%) in responsive patients following ECT. No significant increase was seen in non-responders. These results suggest that successful ECT may be associated with elevated serum GDNF levels.

PMID:
19896212
DOI:
10.1016/j.psychres.2009.01.011
[Indexed for MEDLINE]

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