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Psychiatry Res. 2009 Dec 30;170(2-3):273-5. doi: 10.1016/j.psychres.2009.01.011. Epub 2009 Nov 6.

Electroconvulsive therapy increases glial cell-line derived neurotrophic factor (GDNF) serum levels in patients with drug-resistant depression.

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Department of Neurology, ZhongDa Hospital of Southeast University, Nanjing, 210009, People's Republic of China.


Electroconvulsive therapy (ECT) can be effective in patients with depression resistant to pharmacologic medication. We report that serum levels of glial cell-line derived neurotrophic factor (GDNF) were increased following ECT of patients with drug-resistant depression. When patients were sub-classified into ECT responders and non-responders, serum GDNF levels were significantly increased (58%) in responsive patients following ECT. No significant increase was seen in non-responders. These results suggest that successful ECT may be associated with elevated serum GDNF levels.

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