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Biochem Biophys Res Commun. 1991 Jan 15;174(1):6-10.

Elafin is a potent inhibitor of proteinase 3.

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1
Department of Dermatology, University of Kiel, FRG.

Abstract

Elafin, a human skin derived inhibitor of human leukocyte elastase, was tested for inhibitory activity against proteinase 3, an elastin degrading proteinase of neutrophils. The inhibitory activity of elafin was compared with antileukoprotease and eglin C. Elafin proved to be a potent inhibitor of elastin-FITC degradation showing an IC 50 of 9.5 x 10(-9) M. Potency was found to be more than 100-fold higher as compared with antileukoprotease and eglin C.

PMID:
1989620
[Indexed for MEDLINE]
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