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Psychol Med. 2010 Jul;40(7):1063-77. doi: 10.1017/S0033291709991723. Epub 2009 Nov 9.

Genome-wide association studies: a primer.

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1
Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.

Abstract

There have been nearly 400 genome-wide association studies (GWAS) published since 2005. The GWAS approach has been exceptionally successful in identifying common genetic variants that predispose to a variety of complex human diseases and biochemical and anthropometric traits. Although this approach is relatively new, there are many excellent reviews of different aspects of the GWAS method. Here, we provide a primer, an annotated overview of the GWAS method with particular reference to psychiatric genetics. We dissect the GWAS methodology into its components and provide a brief description with citations and links to reviews that cover the topic in detail.

PMID:
19895722
PMCID:
PMC4181332
DOI:
10.1017/S0033291709991723
[Indexed for MEDLINE]
Free PMC Article
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