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J Hum Genet. 2009 Dec;54(12):721-6. doi: 10.1038/jhg.2009.105. Epub 2009 Nov 6.

Major contribution of dominant inheritance to autism spectrum disorders (ASDs) in population-based families.

Author information

1
Clinical Trial Management Center, Nagoya City University Hospital, Nagoya, Japan. nishiyama@minos.ocn.ne.jp

Abstract

Results of twin studies have shown that autism spectrum disorders (ASDs) are attributable to complex multigenic interactions rather than to a single susceptibility gene. However, the growing number of distinct, individually rare genetic causes of ASDs, mostly copy number variations (CNVs), favors an alternative to the polygenic hypothesis, the two-component model, which suggests that ASDs are caused either by de novo mutation or by dominant inheritance from asymptomatic carriers of such a mutation. To verify this hypothesis, we estimated the distribution of ASD-risk among both catchment area-based families and multiplex families. Our results suggest that the models with more than three risk components are preferable to the two-component model. Our results also suggest that the largest proportion of ASD cases is caused by dominant inheritance. We additionally show that Supplementary information regarding prevalence has a crucial role in analyzing proband-ascertained data.

PMID:
19893580
DOI:
10.1038/jhg.2009.105
[Indexed for MEDLINE]

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