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Crit Care Clin. 2009 Oct;25(4):677-702, vii. doi: 10.1016/j.ccc.2009.08.002.

The pathophysiology of septic shock.

Author information

1
Division of Critical Care Medicine, Department of Internal Medicine, Cooper University Hospital, Camden, NJ, USA. Okorie-Okorie@CooperHealth.edu

Abstract

There is a profound cellular dysfunction in sepsis, that clinically manifests as a continuum from simple, uncomplicated sepsis to severe sepsis, and finally to septic shock. Septic shock remains a significant challenge for clinicians. Recent advances in cellular and molecular biology have significantly improved our understanding of its pathogenetic mechanisms. These improvements will translate to better care and improved outcomes for these patients.

PMID:
19892247
DOI:
10.1016/j.ccc.2009.08.002
[Indexed for MEDLINE]

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