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Pediatr Blood Cancer. 2010 May;54(5):663-9. doi: 10.1002/pbc.22265.

Hepato-biliary late effects in survivors of childhood and adolescent cancer: a report from the Children's Oncology Group.

Author information

1
Department of Pediatrics, Wake Forest University, Winston-Salem, NC27157, USA. scastell@wfubmc.edu

Abstract

Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.

PMID:
19890896
PMCID:
PMC2838980
DOI:
10.1002/pbc.22265
[Indexed for MEDLINE]
Free PMC Article

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