Format

Send to

Choose Destination
See comment in PubMed Commons below
J Virol. 2010 Jan;84(2):1189-92. doi: 10.1128/JVI.01712-09. Epub 2009 Nov 4.

Identification of viral microRNAs expressed in human sacral ganglia latently infected with herpes simplex virus 2.

Author information

1
Department of Molecular Genetics and Center for Virology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Abstract

Deep sequencing of small RNAs isolated from human sacral ganglia latently infected with herpes simplex virus 2 (HSV-2) was used to identify HSV-2 microRNAs (miRNAs) expressed during latent infection. This effort resulted in the identification of five distinct HSV-2 miRNA species, two of which, miR-H3/miR-I and miR-H4/miR-II, have been previously reported. Three novel HSV-2 miRNAs were also identified, and two of these, miR-H7 and miR-H9, are derived from the latency-associated transcript (LAT) and are located antisense to the viral transcript encoding transactivator ICP0. A third novel HSV-2 miRNA, miR-H10, is encoded within the unique long (U(L)) region of the genome, 3' to the U(L)15 open reading frame, and is presumably excised from a novel, latent HSV-2 transcript distinct from LAT.

PMID:
19889786
PMCID:
PMC2798372
DOI:
10.1128/JVI.01712-09
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center