Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Colorectal Dis. 2010 Feb;25(2):205-12. doi: 10.1007/s00384-009-0828-6. Epub 2009 Nov 4.

Association between adiponectin, resistin, insulin resistance, and colorectal tumors.

Author information

1
Department of Medical Oncology, Ondokuz Mayis University Medical School, Kurupelit, 55139 Samsun, Turkey. ggonullu@omu.edu.tr

Abstract

PURPOSE:

In this study, we have examined the correlation between colorectal cancer (CRC) and serum adiponectin and resistin levels, body mass index and insulin resistance.

METHODS:

The relation between serum adiponectin and resistin levels, obesity and insulin resistance in 36 CRC patients and 37 controls was examined.

RESULTS:

Insulin and homeostasis model assessment insulin resistance index (HOMA-IR) levels were higher, and adiponectin levels were significantly decreased in patients versus controls, whereas, resistin levels were significantly increased. A negative correlation between adiponectin, HOMA-IR, and insulin and a positive correlation between HOMA-IR, insulin, and stage were detected. There was no correlation between the stage and resistin. Adiponectin level negatively correlated with the stage. Adiponectin and resistin could play a role in colon cancer carcinogenesis, and adiponectin could be responsible for poor prognosis in colorectal cancer.

Comment in

PMID:
19888587
DOI:
10.1007/s00384-009-0828-6
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center