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Korean J Radiol. 2009 Nov-Dec;10(6):552-8. doi: 10.3348/kjr.2009.10.6.552.

Gray matter concentration abnormality in brains of narcolepsy patients.

Author information

1
Department of Neurology, Sleep Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

Abstract

OBJECTIVE:

To investigate gray matter concentration changes in the brains of narcoleptic patients.

MATERIALS AND METHODS:

Twenty-nine narcoleptic patient with cataplexy and 29 age and sex-matched normal subjects (mean age, 31 years old) underwent volumetric MRIs. The MRIs were spatially normalized to a standard T1 template and subdivided into gray matter, white matter, and cerebrospinal fluid (CSF). These segmented images were then smoothed using a 12-mm full width at half maximum (FWHM) isotropic Gaussian kernel. An optimized voxel-based morphometry protocol was used to analyze brain tissue concentrations using SPM2 (statistical parametric mapping). A one-way analysis of variance was applied to the concentration analysis of gray matter images.

RESULTS:

Narcoleptics with cataplexy showed reduced gray matter concentration in bilateral thalami, left gyrus rectus, bilateral frontopolar gyri, bilateral short insular gyri, bilateral superior frontal gyri, and right superior temporal and left inferior temporal gyri compared to normal subjects (uncorrected p < 0.001). Furthermore, small volume correction revealed gray matter concentration reduction in bilateral nuclei accumbens, hypothalami, and thalami (false discovery rate corrected p < 0.05).

CONCLUSION:

Gray matter concentration reductions were observed in brain regions related to excessive daytime sleepiness, cognition, attention, and memory in narcoleptics with cataplexy.

KEYWORDS:

Hypothalamus; Magnetic resonance (MR); Narcolepsy; Nucleus accumbens; Thalamus; Voxel based morphometry

PMID:
19885310
PMCID:
PMC2770823
DOI:
10.3348/kjr.2009.10.6.552
[Indexed for MEDLINE]
Free PMC Article

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