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Trends Biochem Sci. 2010 Mar;35(3):161-8. doi: 10.1016/j.tibs.2009.10.002. Epub 2009 Oct 31.

GSK3: a multifaceted kinase in Wnt signaling.

Author information

1
Vascular Biology and Therapeutics Program and Department of Pharmacology, Yale University School of Medicine, New Haven, CT 065202, USA. dan.wu@yale.edu

Abstract

GSK3 is one of the few signaling mediators that play central roles in a diverse range of signaling pathways, including those activated by Wnts, hedgehog, growth factors, cytokines, and G protein-coupled ligands. Although the inhibition of GSK3-mediated beta-catenin phosphorylation is known to be the key event in Wnt-beta-catenin signaling, the mechanisms that underlie this event remain incompletely understood. The recent demonstration of GSK3 involvement in Wnt receptor phosphorylation illustrates the multifaceted roles that GSK3 plays in Wnt-beta-catenin signaling. In this review, we will summarize these recent results and offer explanations, hypotheses, and models to reconcile some of these observations.

PMID:
19884009
PMCID:
PMC2834833
DOI:
10.1016/j.tibs.2009.10.002
[Indexed for MEDLINE]
Free PMC Article

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