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J Ethnopharmacol. 2010 Feb 3;127(2):352-6. doi: 10.1016/j.jep.2009.10.031. Epub 2009 Oct 31.

Toxicological evaluation of grains of paradise (Aframomum melegueta) [Roscoe] K. Schum.

Author information

1
Phytomedics, Inc, 1085 Cranbury South River Rd, Suite #8, Jamesburg, NJ 08831, USA.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Grains of Paradise (Aframomum melegueta [Roscoe] K. Schum.) seeds are used in West Africa as a remedy for variety of ailments such as stomach ache, snakebite, diarrhea and they have reported anti-inflammatory properties. Additionally, the seeds contain gingerols and related compounds that may be useful against cardiovascular disease, diabetes, and inflammation.

AIM OF STUDY:

A 28-day sub-chronic toxicity study in male and female Sprague-Dawley rats was conducted to evaluate the safety of a Grains of Paradise extract.

MATERIALS AND METHODS:

An ethanolic extract of the seeds was evaluated for toxicological effect on rats.

RESULTS:

A dose-related increase in absolute and relative liver weights was observed in males and females dosed with 450 and 1500 mg/kg. There was a corresponding increase in alkaline phosphatase with no signs of steatosis or cirrhosis. At the same doses, there was a significant decrease in blood glucose in male rats.

CONCLUSIONS:

This study shows that Grains of Paradise extract may be useful as a treatment for diabetes, however liver toxicity should be considered.

PMID:
19883745
PMCID:
PMC3815460
DOI:
10.1016/j.jep.2009.10.031
[Indexed for MEDLINE]
Free PMC Article

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