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Nat Rev Gastroenterol Hepatol. 2009 Nov;6(11):679-83. doi: 10.1038/nrgastro.2009.165.

Liver transplantation after radioembolization in a patient with unresectable HCC.

Author information

  • 1Department of Medicine, Universidad de Guadalajara, Guadalajara, México.

Abstract

BACKGROUND:

A 58-year-old white man who was being followed by his hepatologist for nonalcoholic steatohepatitis-related liver cirrhosis and portal hypertension and who had been found to have a biopsy-proven hepatocellular carcinoma (HCC) on routine screening, self-referred to our center for a second opinion on the management of his HCC.

INVESTIGATIONS:

Laboratory investigations, CT scan of the abdomen and chest, bone scan and technetium macroaggregated albumin scan.

DIAGNOSIS:

The patient had unresectable HCC.

MANAGEMENT:

The patient underwent two treatments with Yttrium-90 glass microspheres, which were performed as outpatient procedures 1 month and 3 months after diagnosis. He underwent orthotopic liver transplantation (OLT) 1 year after the initial diagnosis of HCC. The post-OLT immunoregimen included OKT3 plus rituximab and high-dose steroids. On discharge from hospital he was on immunosuppressive treatment with tacrolimus. He had de novo autoimmune hepatitis 6 months post-OLT, which was treated with a short course of low-dose steroids and addition of mycophenolate mofetil.

PMID:
19881519
PMCID:
PMC2904913
DOI:
10.1038/nrgastro.2009.165
[PubMed - indexed for MEDLINE]
Free PMC Article
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