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Nat Immunol. 2009 Dec;10(12):1260-6. doi: 10.1038/ni.1821. Epub 2009 Nov 1.

Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment.

Author information

1
Department of Immunology, MD Anderson Cancer Center, Houston, Texas, USA.

Abstract

How naive CD4(+) T cells commit to the T helper type 2 (T(H)2) lineage is poorly understood. Here we show that the basic helix-loop-helix transcription factor Dec2 was selectively expressed in T(H)2 cells. CD4(+) T cells from Dec2-deficient mice showed defective T(H)2 differentiation in vitro and in vivo in an asthma model and in response to challenge with a parasite antigen. Dec2 promoted expression of interleukin 4 (IL-4), IL-5 and IL-13 during early T(H)2 differentiation and directly bound to and activated transcription of genes encoding the transcription factors JunB and GATA-3. As GATA-3 induces Dec2 expression, our findings also indicate a feed-forward regulatory circuit during T(H)2 differentiation.

PMID:
19881507
PMCID:
PMC2784129
DOI:
10.1038/ni.1821
[Indexed for MEDLINE]
Free PMC Article

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