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Appl Environ Microbiol. 2010 Jan;76(1):352-5. doi: 10.1128/AEM.02538-09. Epub 2009 Oct 30.

7-ketocholesterol catabolism by Rhodococcus jostii RHA1.

Author information

1
Department of Civil and Environmental Engineering, Rice University, Houston, TX, USA.

Abstract

Oxysterols from steroid autooxidation have numerous harmful effects, but their biodegradation is poorly understood. Microarrays were used to study mineralization of the most common oxysterol, 7-ketocholesterol (7KC), by Rhodococcus jostii RHA1. Growth on 7KC versus growth on cholesterol resulted in 363 differentially expressed genes, including upregulation of two large gene clusters putatively encoding steroid catabolism. Despite this difference, 7KC degradation required key genes involved in cholesterol degradation, indicating a common catabolic route.

PMID:
19880645
PMCID:
PMC2798662
DOI:
10.1128/AEM.02538-09
[Indexed for MEDLINE]
Free PMC Article

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