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J Clin Epidemiol. 2010 Jun;63(6):647-54. doi: 10.1016/j.jclinepi.2009.08.007. Epub 2009 Oct 31.

A correspondence analysis revealed frailty deficits aggregate and are multidimensional.

Author information

1
Solidage Research Group, Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Quebec, Canada.

Abstract

OBJECTIVE:

To examine the relationships among seven frailty domains: nutrition, physical activity, mobility, strength, energy, cognition, and mood, using data from three studies.

STUDY DESIGN AND SETTING:

Data from three studies were separately analyzed using multiple correspondence analysis (MCA). The graphical output of MCA was used to assess (1) if the presence of deficits in the frailty domains separate from the absence of deficits on the graph, (2) the dimensionality of the domains, (3) the clustering of domains within each dimension, and (4) their relationship with age, sex, and disability. Results were compared across the studies.

RESULTS:

In two studies, presence of deficits for all domains separated from absence of deficits. In the third study, there was separation in all domains except cognition. Three main dimensions were retained in each study; however, assigned dimensionality of domains differed. The clustering of mobility with energy and/or strength was consistent across studies. Deficits were associated with older age, female sex, and disability.

CONCLUSION:

Our results suggest that frailty is a multidimensional concept for which the relationships among domains differ according to the population characteristics. These domains, with the possible exception of cognition, appear to aggregate together and share a common underlying construct.

PMID:
19880286
PMCID:
PMC3718711
DOI:
10.1016/j.jclinepi.2009.08.007
[Indexed for MEDLINE]
Free PMC Article

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