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Cell. 2009 Oct 30;139(3):573-86. doi: 10.1016/j.cell.2009.08.041.

PI3 kinase signals BCR-dependent mature B cell survival.

Author information

1
Program of Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.

PMID:
19879843
PMCID:
PMC2787092
DOI:
10.1016/j.cell.2009.08.041
[Indexed for MEDLINE]
Free PMC Article

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