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Trends Immunol. 2009 Dec;30(12):592-602. doi: 10.1016/j.it.2009.09.009. Epub 2009 Oct 30.

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function.

Author information

1
National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. palmerd@mail.nih.gov

Abstract

Cytokines are key modulators of T cell biology, but their influence can be attenuated by suppressors of cytokine signaling (SOCS), a family of proteins consisting of eight members, SOCS1-7 and CIS. SOCS proteins regulate cytokine signals that control the polarization of CD4(+) T cells into Th1, Th2, Th17, and T regulatory cell lineages, the maturation of CD8(+) T cells from naïve to "stem-cell memory" (Tscm), central memory (Tcm), and effector memory (Tem) states, and the activation of these lymphocytes. Understanding how SOCS family members regulate T cell maturation, differentiation, and function might prove critical in improving adoptive immunotherapy for cancer and therapies aimed at treating autoimmune and infectious diseases.

PMID:
19879803
PMCID:
PMC2787651
DOI:
10.1016/j.it.2009.09.009
[Indexed for MEDLINE]
Free PMC Article

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