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Neurosci Lett. 2010 Jan 14;468(3):195-7. doi: 10.1016/j.neulet.2009.10.078. Epub 2009 Oct 29.

Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.

Author information

1
Center for Experimental Medicine and Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.

Abstract

The proneural protein Neurogenin 2 (NEUROG2) is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons. To determine whether genetic variation in the coding region of the NEUROG2 gene plays a role in the etiology of Parkinson's disease (PD), we screened DNA samples from 202 PD patients and 201 normal controls. No mutation in the NEUROG2 gene was identified in our PD cohort, except that novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.

PMID:
19879328
DOI:
10.1016/j.neulet.2009.10.078
[Indexed for MEDLINE]

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