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FEBS Lett. 2009 Dec 3;583(23):3811-6. doi: 10.1016/j.febslet.2009.10.075. Epub 2009 Oct 29.

Multiple routes of protein transport from endosomes to the trans Golgi network.

Author information

1
Department of Biochemistry, 279 Campus Drive B400, Stanford University School of Medicine, Stanford, CA 94305-5307, USA. pfeffer@stanford.edu

Abstract

Proteins use multiple routes for transport from endosomes to the Golgi complex. Shiga and cholera toxins and TGN38/46 are routed from early and recycling endosomes, while mannose 6-phosphate receptors are routed from late endosomes. The identification of distinct molecular requirements for each of these pathways makes it clear that mammalian cells have evolved more complex targeting mechanisms and routes than previously anticipated.

PMID:
19879268
PMCID:
PMC2787657
DOI:
10.1016/j.febslet.2009.10.075
[Indexed for MEDLINE]
Free PMC Article

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