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Cancer Cell. 2009 Nov 6;16(5):369-77. doi: 10.1016/j.ccr.2009.09.024.

Signaling to p53: ribosomal proteins find their way.

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1
Department of Radiation Oncology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7512, USA. ypzhang@med.unc.edu

Abstract

Inherently disparate cell growth and division, which are intimately coupled through a delicate network of intracellular and extracellular signaling, require ribosomal biogenesis. A number of events imparting instability to ribosomal biogenesis can cause nucleolar stress. In response to this stress, several ribosomal proteins bind to MDM2 and block MDM2-mediated p53 ubiquitination and degradation, resulting in p53-dependent cell cycle arrest. By doing so, the ribosomal proteins play a crucial role in connecting deregulated cell growth with inhibition of cell division. The ribosomal protein-MDM2-p53 signaling pathway provides a molecular switch that may constitute a surveillance network monitoring the integrity of ribosomal biogenesis.

PMID:
19878869
PMCID:
PMC4369769
DOI:
10.1016/j.ccr.2009.09.024
[Indexed for MEDLINE]
Free PMC Article
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