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Cancer Cell. 2009 Nov 6;16(5):366-8. doi: 10.1016/j.ccr.2009.10.007.

PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer.

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1
Division of Molecular Medicine & Genetics, Departments of Internal Medicine, Human Genetics and Pathology, and The Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109-22200, USA. fearon@umich.edu

Abstract

Genetic alternations resulting in constitutive stabilization of beta-catenin and altered transcription of beta-catenin/TCF-regulated genes are found in many cancers. A recent Nature paper offers insights into the role of tankyrase in regulating the Wnt/beta-catenin pathway and suggests that compounds targeting tankyrase's poly-ADP-ribosylation (PARsylation) activity may hold promise for cancer therapy.

PMID:
19878868
DOI:
10.1016/j.ccr.2009.10.007
[Indexed for MEDLINE]
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