Format

Send to

Choose Destination
Clin Endocrinol (Oxf). 2010 Jul;73(1):55-65. doi: 10.1111/j.1365-2265.2009.03742.x.

Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study.

Author information

1
Clinical Research Branch, National Institute on Aging, 3001 S. Hanover Street, Baltimore, MD 21225, USA. stenholmsm@mail.nih.gov

Abstract

OBJECTIVES:

Adipose tissue-derived inflammation may contribute to metabolic alterations and eventually to the metabolic syndrome (MetS). The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons.

DESIGN:

Cross-sectional population-based InCHIANTI study.

SUBJECTS:

A total of 944 community-dwelling adults aged 65 years and older living in Tuscany, Italy.

MEASUREMENTS:

Obesity was defined as body mass index > or =30 kg/m2 and MetS as > or =3 of the ATP-III criteria. Circulating levels of C-reactive protein, interleukin (IL)-6, IL-1 receptor antagonist (IL-1ra), IL-18, tumour necrosis factor (TNF)-alpha R1, adiponectin, resistin and leptin were measured. Additionally, insulin resistance was determined using the homeostasis model assessment (HOMA-IR).

RESULTS:

The prevalence of the MetS was 32%. Both overall and abdominal obesity were significantly associated with the MetS after adjusting for inflammatory cytokines, adipokines and lifestyle factors. After adjusting for multiple confounders and HOMA-IR, IL-1ra, TNF-alpha R1 and adiponectin (P < 0.05) remained significantly associated with the MetS. Having multiple cytokines in the highest tertile increased the likelihood of having the MetS in both obese (P for trend 0.002) and non-obese persons (P for trend 0.001) independent of insulin resistance.

CONCLUSIONS:

Non-obese and obese individuals who develop an intense pro-inflammatory state may be more prone to develop the MetS than those with lower levels of inflammation.

PMID:
19878507
PMCID:
PMC2888845
DOI:
10.1111/j.1365-2265.2009.03742.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center