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Aging Cell. 2010 Feb;9(1):96-9. doi: 10.1111/j.1474-9726.2009.00531.x. Epub 2009 Oct 30.

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts.

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1
Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Abstract

Mitochondrial DNA (mtDNA) mutations are a cause of human disease and are proposed to have a role in human aging. Clonally expanded mtDNA point mutations have been detected in replicating tissues and have been shown to cause respiratory chain (RC) defects. The effect of these mutations on other cellular functions has not been established. Here, we investigate the consequences of RC deficiency on human colonic epithelial stem cells and their progeny in elderly individuals. We show for the first time in aging human tissue that RC deficiency attenuates cell proliferation and increases apoptosis in the progeny of RC deficient stem cells, leading to decreased crypt cell population.

PMID:
19878146
PMCID:
PMC2816353
DOI:
10.1111/j.1474-9726.2009.00531.x
[Indexed for MEDLINE]
Free PMC Article
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