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Trends Biochem Sci. 2010 Feb;35(2):101-8. doi: 10.1016/j.tibs.2009.09.001. Epub 2009 Oct 28.

Assembly of checkpoint and repair machineries at DNA damage sites.

Author information

1
Department of Anatomy, Centre for Cancer Research, University of Hong Kong, L1-59, Laboratory Block, 21 Sassoon Road, Hong Kong SAR.

Abstract

The remarkably coordinated nature of the DNA damage response pathway relies on numerous mechanisms that facilitate the assembly of checkpoint and repair factors at DNA breaks. Post-translational modifications on and around chromatin have critical roles in allowing the timely and sequential assembly of DNA damage responsive elements at the vicinity of DNA breaks. Notably, recent advances in forward genetics and proteomics-based approaches have enabled the identification of novel components within the DNA damage response pathway, providing a more comprehensive picture of the molecular network that assists in the detection and propagation of DNA damage signals.

PMID:
19875294
PMCID:
PMC3209802
DOI:
10.1016/j.tibs.2009.09.001
[Indexed for MEDLINE]
Free PMC Article

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