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J Neuroimmunol. 2009 Dec 10;217(1-2):51-4. doi: 10.1016/j.jneuroim.2009.09.020. Epub 2009 Oct 28.

Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen.

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1
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 5294-0005, USA. poreilly@uab.edu

Abstract

Prolyl endopeptidase (PE), a protease that cleaves after proline residues in oligopeptides, is highly active in brain and degrades neuropeptides in vitro. We have recently demonstrated that PE, in concert with MMP's, can generate PGP (proline-glycine-proline), a novel, neutrophil chemoattractant, from collagen. In this study, we demonstrate that human peripheral blood neutrophils contain PE, which is constitutively active, and can generate PGP de novo from collagen after activation with LPS. This novel, pro-inflammatory role for PE raises the possibility of a self-sustaining pathway of neutrophilic inflammation and may provide biomarkers and therapeutic targets for diseases caused by chronic, neutrophilic inflammation.

PMID:
19875179
PMCID:
PMC2787998
DOI:
10.1016/j.jneuroim.2009.09.020
[Indexed for MEDLINE]
Free PMC Article

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